Discovering the Potential Role of the C2 DUSP2+ MCs Subgroup in Lung Adenocarcinoma.

ABSTRACT:

Objective

In both industrialized and developing nations worldwide, lung adenocarcinoma is one of the deadliest malignant tumors and the primary cause of cancer-related deaths. Its cellular heterogeneity is unclear to the fullest extent, although in recent years, its prevalence in younger individuals has increased. Therefore, it is urgent to deepen the understanding of lung adenocarcinoma and explore new therapeutic methods.

Methods

CytoTRACE, Monocle, SCENIC, and enrichment analysis were used to analyze the single cell RNA data, we characterized the biological characteristics of mast cells (MCs) in lung adenocarcinoma patient samples. CellChat was used to analyze and validate the interaction between MCs and tumor cells in lung adenocarcinoma. Prognostic models were used to e

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11910677 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature