A comprehensive transcriptional profiling of developing gonads reveals the role of TGFβ signaling in female gonadal asymmetry in chickens.

ABSTRACT: Asymmetrical gonadal development is an intriguing phenomenon observed in the majority of female birds. In chickens, the left gonad of female embryos develops into a functional ovary, while the right gonad undergoes degeneration during embryogenesis. This sexually dimorphic trait is primarily induced by the spatial differential expression of the paired like homeodomain 2 (PITX2) gene. However, a comprehensive understanding of the transcriptional profile of the developing gonads during asymmetric development is still lacking. To elucidate the molecular mechanism of asymmetric gonadal development in chickens, we compared the transcriptomes between left and right gonads of female chickens using bulk- and single cell-RNA sequencing (scRNA-seq) approaches. Our bulk RNA-seq analysis of the female

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC11910708 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature