Association of Pre-Lung Transplant Opioid Use With Posttransplant Opioid Use and Outcomes.

ABSTRACT:

Background

Preoperative opioid use (OU) is a strong risk factor for poor postoperative outcomes in other surgical populations but has not been explored in lung transplant (LT) recipients nationally.

Methods

The study identified adult (aged ≥18 years) US lung transplant (LT) recipients from 2011 to 2021 in the Scientific Registry of Transplant Recipients with prescription data through a pharmacy data set. Posttransplantation ventilatory support, infection, and mortality by pretransplantation OU (prescription fill ≤6 months before transplantation) were compared using multivariable regression.

Results

Among 17,285 LT recipients, 17.9% had pretransplantation OU. The odds of posttransplantation opioid prescription fill were 3.18-fold higher 0 to 6 months after transplantat

SUBMITTER: Ruck JM 

PROVIDER: S-EPMC11910811 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature