Circulating miR-486-3p as a potential biomarker for the diagnosis of gestational diabetes mellitus and the prediction of adverse pregnancy outcomes.

ABSTRACT:

Objective

Gestational diabetes mellitus (GDM) seriously endangers the health of pregnant women and their offspring. Early prediction and diagnosis allow timely treatment of GDM, preventing adverse pregnancy outcomes and related diseases. This research aims to explore the predictive significance of miR-486-3p expression levels in diagnosing GDM in early pregnancy.

Methods

A retrospective study was conducted by enrolling 103 subjects with GDM and 98 healthy subjects. qRT-PCR was used to analyze the expression level of miR-486-3p. The chi-square test and t-test were used to evaluate the differences in miR-486-3p expression levels between the GDM and control groups. The predictive value of miR-486-3p in early diagnosis of GDM was analyzed by receiver operating characteristic (RO

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11910836 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature