PLZF-expressing CD4⁺ T cells promote tissue-resident memory T cells in breaking immune tolerance in allergic asthma via IL-15/IL-15Rα signaling.

ABSTRACT:

Background

Allergic asthma is a chronic airway disease characterized by an allergic response and altered immune tolerance. CD4⁺ tissue-resident memory T (TRM) cells are crucial in the chronic and relapsing pathogenesis of asthma. Furthermore, promyelocytic leukemia zinc finger (PLZF) is an essential transcription factor involved in asthmatic tolerance and has been implicated in the regulation of CD4⁺CD44⁺ memory T cells. However, the role of CD4⁺ TRM cells in asthmatic tolerance, as well as their potential modulation by PLZF, remain unclear. Therefore, in the current study, we explore the role of CD4⁺ TRM cells in asthmatic immune tolerance and as well as the regulatory role of PLZF in this process.

Methods

To elucidate

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11910871 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature