Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective.

ABSTRACT: Traditional medicines serve not only as an integral part of medical treatments prescribed by healthcare providers but also as a fundamental reservoir for novel molecular scaffolds. However, gaps remain in our understanding of the mechanisms underlying their activity. A superfamily of membrane proteins, G protein-coupled receptors (GPCRs), have been demonstrated to be potential targets for several compounds isolated from traditional medicines. Given that GPCRs serve as targets for approximately one-third of all marketed drugs, they may be compelling targets for repurposing traditional medicines. Despite this potential, research investigating their activity or potential ligands across GPCRome, the library of human GPCRs, is scarce. Drawing on the functional and structural knowledge presently

SUBMITTER: Bi Z 

PROVIDER: S-EPMC11910885 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature