Maternal influenza vaccination and associated risk of fetal loss: A claims-based prospective cohort study.

ABSTRACT:

Background

Although numerous studies support the safety of influenza vaccination during pregnancy, fewer studies have evaluated the risk of miscarriage or considered the effect of prior immunization.

Methods

Using national de-identified administrative claims data from the Optum Labs Data Warehouse, we conducted a claims-based cohort study of 117,626 pregnancies between January 2009 and December 2018. We identified pandemic A(H1N1)pdm09 and seasonal influenza vaccinations using CPT codes. Fetal loss was defined as miscarriage, medical termination, or stillbirth as identified by ICD-10-CM diagnostic codes. Cox proportional hazard models treating influenza vaccination as a time-varying exposure, weighted for loss-to-follow-up and stratified by baseline probability of vaccinatio

SUBMITTER: Regan AK 

PROVIDER: S-EPMC11911014 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature