Proteomic analysis and effects on osteogenic differentiation of exosomes from patients with ossification of the spinal ligament.

ABSTRACT: Ossification of the spinal ligament (OSL), including ossification of the posterior longitudinal ligament and ossification of the ligamentum flavum (OLF), is a multifactorial disease that includes genetic predisposition. The association between the rate of ossification in the spinal canal and the severity of myelopathy symptoms is well known, but the degree of progression varies widely among patients. Although many candidate genes and biomarkers have been reported, there are no definitive and quantitative conclusions to date, probably because of low reproducibility due to individual differences. In this study, we focused on exosomes secreted by ossified spinal ligament cells. Exosomes are crucial for intercellular communication during development and progression of disease. In a co-culture

SUBMITTER: Nakajima H 

PROVIDER: S-EPMC11911064 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature