Unveiling the Role of Protein Posttranslational Modifications in Glioma Prognosis.

ABSTRACT:

Background

Gliomas represent the most aggressive malignancies of the central nervous system, with posttranslational modifications (PTMs) emerging as critical regulators of oncogenic processes through dynamic protein functional modulation. Despite their established role in tumor biology, the systematic characterization of PTM-mediated molecular mechanisms driving glioma progression remains unexplored. This study aims to uncover the molecular mechanisms of glioma, with a focus on the role of PTMs.

Methods

We analyzed the PTM pathway to classify glioma patients into distinct clusters. Comprehensive analyses compared intercluster differences in clinical outcomes, mutational landscapes, and immune microenvironment profiles. Differentially expressed genes (DEGs) were identified to

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC11911106 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature