No reliable gray matter alterations in idiopathic dystonia.

ABSTRACT:

Background

The structural brain abnormalities associated with idiopathic dystonia (ID) remain inadequately understood. Previous voxel-based morphometry (VBM) studies examining whole-brain gray matter (GM) volume alterations in patients with ID have reported inconsistent and occasionally contradictory findings.

Methods

We performed a coordinate-based meta-analysis (CBMA) using the latest seed-based d mapping with permutation of subject images (SDM-PSI) technique to identify consistent GM alterations in patients with ID at the whole-brain level. Additionally, meta-regression analyses were conducted to explore the potential moderating effects of age, gender, and disease duration on GM volume.

Results

The CBMA incorporated 27 VBM studies, comprising 32 datasets with a tot

SUBMITTER: Wang ZY 

PROVIDER: S-EPMC11911186 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature