PRR13 expression as a prognostic biomarker in breast cancer: correlations with immune infiltration and clinical outcomes.

ABSTRACT:

Introduction

Breast cancer continues to be a primary cause of cancer-related mortality among women globally. Identifying novel biomarkers is essential for enhancing patient prognosis and informing therapeutic decisions. The PRR13 gene, associated with taxol resistance and the progression of various cancers, remains under-characterized in breast cancer. This study aimed to investigate the role of PRR13 in breast cancer and its potential as a prognostic biomarker.

Methods

We performed a comparative analysis of PRR13 gene expression utilizing the TCGA database against non-cancerous tissues and employed STRING to evaluate PRR13's protein-protein interactions and associated pathways. Additionally, we investigated the relationship between PRR13 mRNA expression and immune cell infi

SUBMITTER: Meng M 

PROVIDER: S-EPMC11911201 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature