Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice.

ABSTRACT:

Introduction

Alterations of the adaptive immune system have been shown to impact bone healing and may result in impaired healing in some patients. Apart from T cells, B cells are the key drivers of adaptive immunity. Therefore, their role in age-associated impairments of bone healing might be essential to understand delays during the healing process. B cells are essential for bone formation, and their dysfunction has been associated with aging or autoimmune diseases. But whether age-associated changes in B cell phenotypes are involved in bone regeneration is unknown.

Methods

Here, we aimed to characterize the role of immune aging in B cell phenotypes during the early inflammatory phase of bone healing. By comparing non-immune experienced with young and immune experienced mic

SUBMITTER: Tchouto MN 

PROVIDER: S-EPMC11911212 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature