White Matter Microstructure Among Straight and Gay Cisgender Men, Sao Praphet Song, and Straight Cisgender Women in Thailand.

ABSTRACT: White matter (WM) microstructure is differentiated in relation to sex/gender, psychosexuality, and, among transgender people, gender-affirming hormone (GAH) use. Prior research focused on Western samples, which limits generalizability to other populations. Here, diffusion tensor imaging (DTI) was used to assess WM microstructure in a Thai sample (N = 128) of straight cisgender men, straight cisgender women, gay cisgender men, and sao praphet song (i.e., transfeminine individuals assigned male at birth and sexually attracted to cisgender men). Sao praphet song were further grouped by GAH use. Groups were compared on fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) using whole-brain tract-based spatial statistics (TBSS). FA, AD, and RD we

SUBMITTER: Thurston LT 

PROVIDER: S-EPMC11911223 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature