Paracetamol, its metabolites, and their transfer between maternal circulation and fetal brain in mono- and combination therapies.

ABSTRACT:

Background

Due to its availability and perceived safety, paracetamol is recommended even during pregnancy and for neonates. It is used frequently alone or in combination with other drugs required for the treatment of various chronic conditions. The aim of this study was to investigate potential effects of drug interactions on paracetamol metabolism and its placental transfer and entry into the developing brain.

Methods

Sprague Dawley rats at postnatal day P4, pregnant embryonic day E19 dams, and non-pregnant adult females were administered paracetamol (15 mg/kg) either as monotherapy or in combination with one of seven other drugs: cimetidine, digoxin, fluvoxamine, lamotrigine, lithium, olanzapine, valproate. Concentrations of parent paracetamol and its metabolites (paraceta

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11911254 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature