Multi-omics analysis identifies OSGEPL1 as an oncogene in hepatocellular carcinoma.

ABSTRACT:

Purpose

N6-Threonylcarbamoyladenosine (t⁶A) modification irregularities and their associated enzymes genes (OSGEP, OSGEPL1, TPRKB, GON7, TP53RK, YRDC, and LAGE3) are linked to various malignancies development, including Hepatocellular Carcinoma (HCC), yet the specific mechanisms remain obscure. This gap in knowledge is significant, as understanding the mechanisms of t⁶A modification could reveal new insights into HCC pathogenesis and potentially identify novel therapeutic targets.

Methods

We leveraged data from The Cancer Genome Atlas (TCGA) to analyze the expression of t⁶A-associated genes, with a focus on OSGEPL1 in HCC. Our analyses included survival outcome, gene expression, functional enrichment, immune cell infiltration, and somatic mut

SUBMITTER: Mui S 

PROVIDER: S-EPMC11911280 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature