Prognostic analysis and identification of M7G immune-related genes in lung squamous cell carcinoma.

ABSTRACT:

Background

In recent years, the clinical application of targeted therapies and immunotherapy has significantly improved survival outcomes for patients with lung adenocarcinomas(LUAD). However, due to fewer mutations, lung squamous cell carcinomas(LUSC) shows limited efficacy with targeted and immunotherapy, resulting in a notably lower 5-year survival rate compared to lung adenocarcinoma. The m7G modification plays an important role in tumorigenesis, progression, immune evasion, and therapeutic response. This study aims to develop a novel scoring system based on m7G modification and immune status to clinically predict the prognosis of patients with LUSC and to provide new therapeutic targets.

Methods

In this study, we utilized RNA-seq data from the TCGA-LUSC database as the

SUBMITTER: Wenhui L 

PROVIDER: S-EPMC11911325 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature