Causal effects of metabolites on malignant neoplasm of bone and articular cartilage: a mendelian randomization study.

ABSTRACT:

Objective

Previous research has demonstrated that metabolites play a significant role in modulating disease phenotypes; nevertheless, the causal association between metabolites and malignant malignancies of bones and joint cartilage (MNBAC)has not been fully elucidated.

Methods

This study used two-sample Mendelian randomization (MR) to explore the causal correlation between 1,400 metabolites and MNBAC. Data from recent genome-wide association studies (GWAS) involving 8,299 individuals were summarized. The GWAS summary data for metabolites were acquired from the IEU Open GWAS database, while those for MNBAC were contributed by the Finnish Consortium. We employed eight distinct MR methodologies: simple mode, maximum likelihood estimator, MR robust adjusted profile score, MR-Eg

SUBMITTER: Du Y 

PROVIDER: S-EPMC11911353 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature