Molecular mechanism on autophagy associated cardiovascular dysfunction in <i>Drosophila melanogaster</i>.

ABSTRACT: As a highly conserved cellular process, autophagy has been the focus of extensive research due to its critical role in maintaining cellular homeostasis and its implications in cardiovascular pathogenesis. The decline in muscular function, along with the neuronal system, and increased sensitivity to stress have been recognized in multiple animal models. Autophagic defects in cardiovascular architecture and cellular dysfunction have been linked to both physiological and pathological conditions of the heart in mammals and Drosophila. In this review, we systematically analyze the autophagy-associated pathways in the hearts of fruit flies and aim to provide a comprehensive understanding for developing potential treatments for patients and effective strategies for agricultural application

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11911378 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature