Drosophila ovarian stem cell niche ageing involves coordinated changes in transcription and alternative splicing.

ABSTRACT: Gene expression (GE) and alternative splicing (AS) contribute to the formation of new interaction networks with potentially significant cellular functions. Here, we investigate ageing in the Drosophila female germline stem cell (GSC) niche and describe functional changes in both GE and AS. The GSC niche comprises three types of support cells, whose ageing transcriptomes reveal differential GE and AS variations related to cell adhesion, cytoskeleton and neural signalling. Because each population show distinctive GE and AS changes, niche cell types possess unique ageing signatures. Depending on the cell population, groups of genes display changes in both GE and AS, revealing a coordinated regulation of transcription and splicing during niche ageing. One such gene is Fasciclin 2, a neural adh

SUBMITTER: Even-Ros D 

PROVIDER: S-EPMC11911433 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature