Exploring NUP62's role in cancer progression, tumor immunity, and treatment response: insights from multi-omics analysis.

ABSTRACT:

Background

NUP62, a key component of the nuclear pore complex, is closely associated with cellular functions and cancer progression. However, its expression patterns, prognostic value, and relationship with tumour immunity and drug sensitivity across multiple cancers have not been systematically studied. This study used multi-omics analyses combined with experimental validation in gastric cancer to investigate the expression, functional characteristics, and clinical relevance of NUP62 in cancer.

Methods

Data from TCGA, GTEx, and CPTAC databases were used to analyse the expression, mutation characteristics, and clinical associations of NUP62. Tools such as SangerBox, TIMER 2.0, and GSEA were employed to evaluate the relationship between NUP62 and the tumour immune microenviro

SUBMITTER: Chen L 

PROVIDER: S-EPMC11911477 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature