A comprehensive analysis of the genomic and proteomic profiles of a megalocytivirus isolated from <i>Larimichthys crocea</i>.

ABSTRACT:

Introduction

The prevalence of viral diseases has posed significant challenges to the sustainable development of large yellow croaker (Larimichthys crocea) aquaculture, with megalocytivirus being one of the primary viral pathogens affecting this species. There have been two proteomic and genomic studies regarding two members of the genus Megalocytivirus: the spotted knifejaw iridovirus (SKIV) and the infectious spleen and kidney necrosis virus (ISKNV). However, both studies were conducted more than 10 years ago. To further investigate the pathogenesis of megalocytivirus, we sequenced the genome of the viral strain FD201807 isolated from L. crocea, and conducted a proteomics analysis.

Methods

Viral DNA was sequenced using the Illumina HiSeq 2000 platform.

SUBMITTER: Liu X 

PROVIDER: S-EPMC11911517 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature