Factors Involved in Thymic Atrophy in Severely Malnourished Children: A Systemic Review and Meta-Analysis.

ABSTRACT: To determine leptin's effect on the thymus, we gathered data on leptin levels, ghrelin, cortisol and cytokine levels. The aim of the study was to map leptin's effect on the thymus when malnourished. Pubmed and Embase were searched for articles by the search terms 'malnutrition' and 'leptin'. The risk of bias was assessed by using JBI critical appraisal tools. Results were presented in tables and forest plots generated using STATA. A total of 16 articles were included. All articles included in the study are researching leptin, cortisol, or ghrelin, as well as cytokines. Forest plots were created for leptin, ghrelin, cortisol, Interleukin 10 (IL-10) and Interferon gamma (IFN-γ). Leptin had an overall effect size of 3.01 (95% CI 0.51; 5.51), ghrelin had an overall effect size of -1.71 (-2.97,

SUBMITTER: Lindebjerg C 

PROVIDER: S-EPMC11911552 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature