The in-hospital administration of sacubitril/valsartan in acute myocardial infarction: A meta-analysis.

ABSTRACT: There is a need to address the evidence gap regarding the in-hospital administration of sacubitril/valsartan in acute myocardial infarction patients. After searching MEDLINE, Google Scholars and Scopus, a random-effects meta-analysis of randomized controlled trials comparing the in-hospital administration of the angiotensin receptor-neprilysin inhibitors (ARNis) versus the standard therapy in patients with reduced heart failure due to myocardial infarction was performed. The primary outcome was major adverse cardiovascular events. All-cause mortality, cardiac death, rehospitalization for heart failure, non-fatal myocardial infarction (MI), changes in left ventricular ejection fraction, left ventricular volumes, N terminal pro brain natriuretic peptide and adverse events were the secondary

SUBMITTER: Di Pietro G 

PROVIDER: S-EPMC11911573 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature