Growth differentiation factor-15 and N-terminal pro-BNP in acute heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Heart failure with preserved ejection fraction (HFpEF) continues to be an increasingly common health problem associated with a high mortality rate. Elevated levels of Growth differentiation factor-15 (GDF15) and N-terminal pro-brain natriuretic peptide (NT-proBNP) are reportedly associated with poor clinical outcomes in a broad range of cardiovascular diseases. The aim of the present study was to examine the effect of the combined assessment of these markers on clinical outcomes in patients with HFpEF.

Methods

This study is the prospective observational study. We measured the serum levels of GDF15 and NT-proBNP in 643 patients (mean age 73 ± 12, 42% females). All patients were prospectively followed up for a median period of 1998 days. Total 132 HF-related events and 88

SUBMITTER: Otaki Y 

PROVIDER: S-EPMC11911576 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature