Causal correlations between inflammatory proteins and heart failure: A two-sample Mendelian randomization analysis.

ABSTRACT:

Aims

Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation-related proteins and HF risk remains unclear. This study aims to investigate the genetically supported causality between inflammatory proteins and HF using a two-sample Mendelian randomization (MR) analysis.

Methods and results

We utilized genome-wide association study (GWAS) data of 91 inflammation-related proteins as exposures from the SCALLOP Consortium (14,824 participants), alongside outcome GWAS summary statistics from FinnGen (29,218 cases/381,838 controls) and HERMES (47,309 cases/930,014 controls) for HF, to conduct a two-sample MR analysis. For each

SUBMITTER: Zhu XG 

PROVIDER: S-EPMC11911586 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature