Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy.

ABSTRACT:

Background and aims

The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress. Hypertrophic cardiomyopathy (HCM) is a common heart condition, affecting approximately 15% of the general cat population. Feline HCM shares phenotypical and genotypical similarities with human HCM, but the disease mechanisms for both species are incompletely understood. Our goal was to characterize global changes in metabolome between healthy control cats and cats with different stages of HCM.

Methods

Serum samples from 83 cats, the majority (70/83) of which were domestic shorthair and included 23 healthy control cats, 31 and 12 prec

SUBMITTER: Li Q 

PROVIDER: S-EPMC11911622 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature