Immunotherapy response in immunosuppressed patients with Merkel cell carcinoma: analysis of 183 patients.

ABSTRACT:

Objective

Merkel cell carcinoma (MCC) is an aggressive skin cancer with poor outcomes in immunosuppressed patients. While immune checkpoint inhibitors (ICIs) achieve ~60% response rates in immunocompetent MCC patients, their efficacy in immunosuppressed patients remains unclear due to exclusion from trials. This study compares ICI outcomes, safety and the impact of immunosuppression subtypes between these groups.

Methods and analysis

This retrospective study analysed 183 advanced MCC patients on first-line ICIs from a Seattle-based data repository. Of these, 147 were immunocompetent, and 36 were immunosuppressed (chronic lymphocytic leukaemia (CLL) n=10, autoimmune disorders n=10, other haematologic malignancies n=9, solid organ transplants n=4 and HIV/AIDS n=3). Outcomes in

SUBMITTER: Gong E 

PROVIDER: S-EPMC11911694 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature