Association of plasma metabolites with treatment response after intravitreal anti-vascular endothelial growth factor injections in treatment-naive neovascular age-related macular degeneration.

ABSTRACT:

Background/aims

To investigate the association between plasma metabolomic profiles and treatment response after intravitreal anti-vascular endothelial growth factor (VEGF) injections in treatment-naïve neovascular age-related macular degeneration (nAMD).

Methods

This is part of a prospective longitudinal study that included patients with treatment-naïve nAMD who have undergone three loading intravitreal anti-VEGF injections. All patients underwent ophthalmological examinations including spectral domain optical coherence tomography (SD OCT). Fasting blood samples were collected at the time of study enrolment (not to first anti-VEGF injection) and metabolomic profiling was conducted using ultra-performance liquid chromatography-mass spectrometry. Treatment response was defined

SUBMITTER: Kang HM 

PROVIDER: S-EPMC11911696 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature