Association of ceramide risk scores with rheumatoid arthritis: a FINRISK population-based cohort study.

ABSTRACT:

Objectives

This study aimed to explore the association between lipid-based Cardiovascular Event Risk Tests (CERT1 and CERT2), including ceramides (Cer) and phosphatidylcholine (PC) lipid species, and rheumatoid arthritis (RA), an inflammatory disease that can increase the risk of cardiovascular diseases.

Design

Prospective population-based cohort study.

Setting

Primary care centres across five geographical areas in Finland.

Methods

The study included 7702 individuals (selected from the FINRISK cohort) who were assessed for the prevalence and incidence of RA. At baseline, the cohort included 7518 RA-free individuals, among whom 329 developed RA during the study, and 184 had a history of RA at baseline. Serum levels of ceramides and PC were measured using mass sp

SUBMITTER: Shoghli M 

PROVIDER: S-EPMC11911702 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature