Impact of resection margin width on local recurrence following breast-conserving surgery and whole breast radiotherapy for pure ductal carcinoma in situ: a systematic review and meta-analysis.

ABSTRACT:

Objective

The aim of this study was to determine the impact of margin width and boost radiotherapy on the local recurrence risk of pure ductal carcinoma in situ (DCIS).

Methods and analysis

This is a prospectively registered systematic review and meta-analysis reporting relative risk (RR), OR and HR margin width outcomes. Eligible studies included prospective and retrospective case series with defining margin widths and 48 months of minimum follow-up. All patients (100%) received adjuvant whole breast radiotherapy (WBRT).

Results

A total of 40 265 patients with pure DCIS in 31 studies were included. ORs and RR were calculated from 15 studies in 12 519 patients, and HRs were calculated from 12 studies in 12 946 patients. Local recurrence was significantly greater with

SUBMITTER: Ezzat A 

PROVIDER: S-EPMC11911704 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature