Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to Plasmodium falciparum-Infected Mosquito Bites.

ABSTRACT:

Background

Measuring malaria transmission intensity using the traditional entomological inoculation rate is difficult. Antibody responses to mosquito salivary proteins like SG6 have been used as biomarkers of exposure to Anopheles mosquito bites. Here, we investigate 4 mosquito salivary proteins as potential biomarkers of human exposure to mosquitoes infected with Plasmodium falciparum: mosGILT, SAMSP1, AgSAP, and AgTRIO.

Methods

We tested population-level human immune responses in longitudinal and cross-sectional plasma from individuals with known P falciparum infection from low- and moderate-transmission areas in Senegal using a multiplexed magnetic bead-based assay.

Results

AgSAP and AgTRIO were the best indicators of recent exposure to infected mosquitoes. Antibod

SUBMITTER: Lapidus S 

PROVIDER: S-EPMC11911913 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature