Identification of Fanconi anemia pathway genes as novel prognostic biomarkers and therapeutic targets for breast cancer.

ABSTRACT:

Background

Globally, breast cancer is one of the most common cancers with poor prognosis. The Fanconi anemia (FA) pathway genes maintain genome stability and play important roles in human diseases, including cancer. However, the prognostic values and biological roles of FA pathway genes in breast cancer have not been clarified. This study aims to investigate the potential of FA pathway genes as prognostic biomarkers and therapeutic targets in breast cancer.

Methods

In this study, the Oncomine Cancer Microarray (ONCOMINE), University of ALabama at Birmingham Cancer (UALCAN), Kaplan-Meier plotter, cBio Cancer Genomics Portal (cBioPortal), Gene Expression Profiling Interactive Analysis (GEPIA), Gene Multi-Association Network Integration Algorithm (GeneMANIA), the Database for A

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11912030 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature