Construction and validation of a cell death-related genes prognosis signature of hepatocellular carcinoma.

ABSTRACT:

Background

The cell death pathway, including apoptosis, autophagy, and necroptosis, plays an essential role in hepatocellular carcinoma (HCC) progression and outcome. However, the integration of the three cell death pathways into a prognostic signature has not yet been reported in HCC. This study aimed to investigate the association among cell death-related genes (CDRGs), prognosis, immune microenvironment, and immune checkpoint.

Methods

The RNA expression profiles and corresponding clinical data of HCC were retrieved from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and International Cancer Genome Consortium (ICGC). Univariate Cox regression analysis was performed to identify the relevant prognostic genes, and Lasso Cox regression analysis was employed to

SUBMITTER: Ma Y 

PROVIDER: S-EPMC11912031 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature