Specific effects of hypoxia-immune core gene <i>ARHGAP11A</i> on lung adenocarcinoma.

ABSTRACT:

Background

The changes in tumor microenvironment (TME) are closely related to the regulation of immunity and hypoxia. This study aimed to investigate the specific effects of ARHGAP11A on the prognosis, immunity, and hypoxia of lung adenocarcinoma (LUAD).

Methods

The core gene ARHGAP11A related to immunity and hypoxia was obtained from a variety of databases, including Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), Tumor Immune Estimation Resource (TIMER), the Search Tool for the Retrieval of Interacting Genes (STRING), HALLMARK gene set, and various analysis methods (differences and single factor Cox analysis). The relationship between the expression level of ARHGAP11A, survival prognosis, immune invasion, and h

SUBMITTER: Sun K 

PROVIDER: S-EPMC11912037 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature