Constructing and validating a novel prognostic risk score model for rectal cancer based on four immune-related genes.

ABSTRACT:

Background

Immunotherapy is playing an increasing role in the treatment of various cancers. However, its application in rectal cancer is very limited as only microsatellite-unstable bowel cancers with defective mismatch repair are found to benefit. The majority of rectal cancers belong to the microsatellite-stable phenotype. Therefore, the aim of this study is to explore immune-related genes within the tumor microenvironment of rectal cancer, with the objective of discovering novel biomarkers and therapeutic targets for rectal cancer, and to establish a new prognostic prediction model for rectal cancer based on these immune-related genes.

Methods

The data in The Cancer Genome Atlas (TCGA) database were processed using the Estimation of Stromal and Immune cells in MAlignant T

SUBMITTER: Cai R 

PROVIDER: S-EPMC11912041 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature