Total Astragalus saponins promote ferroptosis in gastric cancer cells by upregulating SIRT3.

ABSTRACT:

Background

Gastric cancer (GC) is a malignant tumor of the digestive tract originating from the epithelial cells of the gastric mucosa, which is highly invasive and heterogeneous, posing a serious threat to human health. In recent years, ferroptosis, as a novel mode of programmed cell death, has shown potential anticancer effects in tumor therapy. Total Astragalus saponins (TAS), a natural product derived from Astragalus membranaceus, have been shown to possess various pharmacological activities, including anticancer effects. This study aimed to investigate the effects of TAS on GC cells, focusing on the mechanism of action of its regulation of the silent information regulator 3 (SIRT3) in inducing ferroptosis in GC cells.

Methods

We treated SGC-7901 cells with TAS at concen

SUBMITTER: Zou Y 

PROVIDER: S-EPMC11912042 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature