Characterization of immune landscape and prognostic value of IL-17-related signature in invasive breast cancer.

ABSTRACT:

Background

Recently, interleukin 17 (IL-17) has been found to play a critical role in the development of breast cancer. However, its prognostic significance in invasive breast cancer (IBC) remains unclear. This study aims to determine the role of IL-17-related signatures in IBC to identify novel therapeutic options.

Methods

IBC data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) were used to identify IL-17-related prognostic genes. A predictive model was developed using TCGA data and validated using METABRIC data. The relationship between IL-17 scores and immune landscape, chemotherapy drug sensitivity [half maximal inhibitory concentration (IC50)], and immune checkpoint gene exp

SUBMITTER: Dong W 

PROVIDER: S-EPMC11912043 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature