A novel necroptosis-related miRNA signature for predicting the prognosis of esophageal cancer and immune infiltration analysis.

ABSTRACT:

Background

The prognostic value of necroptosis-related microRNAs (miRNAs), which are important in tumorigenesis and development, remains unclear. Therefore, we aimed to screen prognostic necroptosis-related miRNAs in esophageal cancer (EC).

Methods

Nine necroptosis-related miRNA expression profiles and associated clinical data of EC patients were obtained from The Cancer Genome Atlas (TCGA) database. The relationships between necroptosis-related miRNAs and overall survival (OS) were determined via Cox regression model analysis. Target genes of the miRNAs were investigated in TargetScan, miRDB, and miRTarBase. The biological functions of these genes were evaluated by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. For the most significant corre

SUBMITTER: Zhang M 

PROVIDER: S-EPMC11912044 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature