Genome-wide profiling of a prognostic RNA-binding protein signature in esophageal cancer.

ABSTRACT:

Background

RNA-binding proteins (RBPs) are known to be involved in the initiation and development of malignant tumors, but the roles of RBPs in esophageal cancer (EC) remain unclear. This study aims to establish a prognostic signature based on RBPs through genome-wide analysis to predict the prognosis of EC patients and provide new insights into chemoresistance.

Methods

The gene expression profiles and clinical data of patients with EC were downloaded from the Xena database. Candidate genes were obtained by taking the intersection of RBP genes, Kyoto Encyclopedia of Genes and Genomes pathway-related genes, and differentially expressed RBP genes from cluster analysis. Hub genes were extracted via protein-protein interaction network construction. A Cox proportional hazards reg

SUBMITTER: Sun S 

PROVIDER: S-EPMC11912045 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature