Diagnostics and immunological function of CENPN in human tumors: from pan-cancer analysis to validation in breast cancer.

ABSTRACT:

Background

Centromere protein N (CENPN), a member of the centromere protein family, contributes to ribonucleic assembly, mitosis progression, and chromosome separation. CENPN manifests a close link with the occurrence and progression of several malignant cancers, but there is no pan-cancer study on CENPN, and we aim to ascertain the connection between CENPN and human cancer prognosis and immunotherapy.

Methods

The CENPN function in multiple malignant tumors was comprehensively investigated with data from The Cancer Genome Atlas (TCGA) and integrated Gene Expression Omnibus (GEO) database. We examined the transcriptional level, prognostic effect, diagnostic value, genetic and epigenetic alteration, methylation level, and immunological import

SUBMITTER: Jing Y 

PROVIDER: S-EPMC11912047 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature