Circulating white blood cell traits, chemokines and small cell lung cancer risk: a Mendelian randomization study.

ABSTRACT:

Background

Small cell lung cancer (SCLC) commonly originates in the context of persistent inflammation. The impact of white blood cell (WBC) counts and the presence of infiltrating inflammatory cytokines in relation to tumor initiation, progression, and treatment response in SCLC remains uncertain. To elucidate the potential relationships of circulating WBCs and chemokines with SCLC, we conducted a univariable (UVMR) and multivariable Mendelian randomization (MVMR) study.

Methods

We conducted a two-sample Mendelian randomization (MR) investigation to evaluate the causal impact of circulating WBCs and chemokines on the risk of SCLC. The genetic data for SCLC were derived from a genome-wide association study (GWAS) involving 24,108 participants, including 2,664 cases and 21,44

SUBMITTER: Zhu H 

PROVIDER: S-EPMC11912050 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature