A prognostic model for laryngeal squamous cell carcinoma based on the mitochondrial metabolism-related genes.

ABSTRACT:

Background

Mitochondrial metabolism-related genes (MMRGs) have emerged as potential therapeutic targets in cancer. This study aimed to construct a prognosis model based on MMRGs for patients with laryngeal squamous cell carcinoma (LSCC).

Methods

Differentially expressed MMRGs in LSCC were identified from The Cancer Genome Atlas (TCGA) and Molecular Signatures Database (MSigDB). Their functions were characterized by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). A prognostic model was established using univariate, least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analyses, and its performance was evaluated using Kaplan-Meier and receiver operating characteristic (ROC) curves. Gene set enrichment analysis (GSEA) wa

SUBMITTER: Hu WM 

PROVIDER: S-EPMC11912054 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature