<i>CALD1</i> inhibits invasion of human ovarian cancer cells by affecting cytoskeletal structure and the number of focal adhesion.

ABSTRACT:

Background

Ovarian cancer (OV) is associated with the highest mortality rate among gynecological cancers, largely due to late diagnosis and chemoresistance. The identification of novel diagnostic markers and therapeutic targets is crucial. Caldesmon 1 (CALD1), a cytoskeleton-regulating protein, has been implicated in various cancers. This study aims to investigate the expression and functional significance of CALD1 in OV, focusing on its potential impact on cell invasion and metastasis.

Methods

We analyzed CALD1 expression using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases, along with tissue microarray immunohistochemistry (IHC). Drug sensitivity analysis was performed using the 'oncopredict' R package. A CALD1 ge

SUBMITTER: Li Y 

PROVIDER: S-EPMC11912064 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature