Expression profile, regulatory mechanism and prognostic potential of MBNL2 in esophageal squamous cell carcinoma.

ABSTRACT:

Background

It remains to refresh the understanding about the pathogenic mechanism of esophageal squamous cell carcinoma (ESCC). This study aimed to profile the expression of muscleblind like protein 2 (MBNL2), as well as its associations with ESCC behaviors.

Methods

Bioinformatic tools were used to mine The Cancer Genome Atlas (TCGA) database for the expression data of MBNL2 in ESCC. The expression of MBNL2 in tissue microarray of 179 ESCC patients was determined by immunohistochemistry (IHC), and the relationship of MBNL2 with patients' clinical and pathological characteristics was analyzed. The expression of MBNL2 was tested in fresh ESCC and adjacent normal tissues in vitro. Experiments about cellular invasion, migration and proliferation were performed to detect t

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11912065 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature