The causal effects of 2,821 protein level ratios on non-small cell lung cancer: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) has a complex etiology, making early diagnosis difficult and leading to high mortality rates, thus necessitating personalized treatment strategies. While protein level ratios have shown potential as biomarkers or therapeutic targets, their causal relationship with NSCLC remains unclear. This study aimed to investigate these causal links using Mendelian randomization (MR), providing insights into potential biomarkers and therapeutic avenues.

Methods

We executed an intricate two-sample MR study to explore the stochastic causal links between 2,821 protein level ratios and NSCLC. The genome-wide association study (GWAS) statistics for NSCLC and protein level ratios were sourced from the Finnish Database (version 10) and the UK Bioban

SUBMITTER: Zou X 

PROVIDER: S-EPMC11912077 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature