Construction and validation of a prognostic model of lncRNAs associated with RNA methylation in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is a common type of lung cancer and one of the leading causes of cancer death worldwide. Long non-coding RNAs (lncRNAs) play a crucial role in tumors. The purpose of this study was to explore the expression of lncRNAs associated with RNA methylation modification and their prognostic value in LUAD.

Methods

The RNA sequencing and clinical data were downloaded from The Cancer Genome Atlas dataset, and the messenger RNA and lncRNAs were annotated by Ensemble. The lncRNAs related to RNA methylation regulators (RMlncRNAs) were filtered by Pearson correlation analysis between differentially expressed lncRNAs and RNA methylation regulators. Univariate Cox regression analysis, multivariate Cox regression analysis, and least absolute shrinkage and

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11912078 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature