Salt-Compact Albumin as a New Pure Protein-based Biomaterials: From Design to In Vivo Studies.

ABSTRACT: Current biodegradable materials are facing many challenges when used for the design of implantable devices because of shortcomings such as toxicity of crosslinking agents and degradation derivatives, limited cell adhesion, and limited immunological compatibility. Here, a class of materials built entirely of stable protein is designed using a simple protocol based on salt-assisted compaction of albumin, breaking with current crosslinking strategies. Salt-assisted compaction is based on the assembly of albumin in the presence of high concentrations of specific salts such as sodium bromide. This process leads, surprisingly, to water-insoluble handable materials with high preservation of their native protein structures and Young's modulus close to that of cartilage (0.86 MPa). Furthermore, the

SUBMITTER: Aloui E 

PROVIDER: S-EPMC11912121 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature