Electromembrane Extraction Provides Unprecedented Selectivity for Drugs in Cell Culture Media Used in Organoid and Organ-on-Chip Systems.

ABSTRACT: The use of organoids and organ-on-chip technologies as nonanimal methodologies in drug discovery and personalized medicine is rapidly expanding. However, the complexity and small volumes of organoid culture samples present significant analytical challenges, e.g., in drug analysis using liquid chromatography-mass spectrometry (LC-MS). Essentially an electrophoresis across an oil membrane, electromembrane extraction (EME) offers a promising approach for measuring drugs, as it is, for example, compatible with small samples such as organoid and organ-on-chip formats. Given the potential of the technology, there is a need to assess the extraction purity of EME extracts to ensure EME's compatibility with high-throughput, downstream analysis. This study evaluates the effectiveness of EME for samp

SUBMITTER: Kogler S 

PROVIDER: S-EPMC11912128 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature