Chip-Based Optoacoustic Single-Cell Detection in Flow Using Point-Source Optimized Surface Acoustic Wave Transducers.

ABSTRACT: Sensitive measurement of the optoacoustic (OA, also photoacoustic) properties of cells in flow is highly desirable, as it provides information about the optical absorption properties of cellular compounds. Hence, optoacoustic spectral characteristics can deliver information about the cell state or disease parameters, but can also be used for high-throughput cell sorting by intrinsic properties without additional fluorescence labeling. The current implementation of optoacoustic measurements of cells in a microfluidic context typically relies on piezoelectric (ultrasound) transducers attached to the microfluidic chip, whereby the transducer records the ultrasound signal originating from absorbing species in cells when excited by laser pulses. The arrangement of the transducer outside of the

SUBMITTER: Gollner S 

PROVIDER: S-EPMC11912191 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature