Dietary habits and risk of diabetic kidney disease: a two-sample and multivariate Mendelian randomization study.

ABSTRACT:

Objective

We explored the causal relationship between certain dietary habits and the risk of developing diabetic kidney disease (DKD) using two-sample Mendelian randomization and multivariate Mendelian randomization.

Research design and methods

This study is based on pooled data from a genome-wide association study (GWAS) of 83 dietary habits in a European population. We performed a two-sample Mendelian randomization analysis using GAWS data on diabetic nephropathy in a European population. Validation was then performed against positive results (p < 0.05) in different GAWS data on diabetic nephropathy of European origin. Finally, multivariate Mendelian randomization analyses were performed on dietary habits with positive results (p < 0.05) in both datasets and

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11912233 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature